The Woman’s seed refers first to Christ, then to the children of God.
And I will put enmity between thee and the woman, and between thy seed and her seed; it shall bruise thy head, and thou shalt bruise his heel. (Gen. 3:15 KJV)
This verse is one of the most famous cruxes of Scripture. Interpreters fall into two categories: those who see in the decree a messianic import and those who see nothing of the kind.-Hamilton, V. P. (1990). The Book of Genesis, Chapters 1–17 (p. 197). Grand Rapids, MI: Wm. B. Eerdmans Publishing Co.
Sound Bible interpretation insists “scripture interprets scripture” to know which side is God’s.
The prophecy telescopes from the Days of Noah the 1st century when Jesus was born, bruised in the heel by the crucifixion, then rose in resurrection to the end time when He will bruise Satan’s Seed the Antichrist in the head.
That is confirmed by the prophecy of the Daughter of Zion who appears first in heaven, gives birth on earth, then waits for deliverance at the return of Christ. “Seed” clearly refers directly to Christ and the Antichrist, then to the children of God or the Devil.
In the war of the seeds begins. Satan cast his Nephilim “fallen ones” down to earth to corrupt the human genome (Rev. 12:1-4; Gen. 6:1-4) hoping to prevent the incarnation of God the Son, in truly human flesh (John 1:14) that reflected the image of God uncorrupted (Gen. 1:26-27).
The flood ended that stage of warfare. Satan and some of his army escaped back into heaven where they forced to remain (Eph. 6:12) until God removes what prevented their physical return to the earth out of the way (2 Thess. 2:6; Rev. 9:1).
But Satan tried to slay the child after it was born (Matt. 2:1-18), but only bruised it by the crucifixion.
In the End Time, when God lifts His restraint of spiritism so Satan and his angels again walk physically among men on earth (Rev. 16:13) as they did in the Days of Noah (Luke 17:26 cf. Matt. 24:29), Michael and his armies cast them out of heaven (Rev. 12:7-13) and they appear on earth claiming to be “Elohim” and Mankind’s “Designers”.
Christ then bruises Adonikam Satan’s seed in the head, at Armageddon (Rev. 19:19-20),
Therefore, it is the testimony of scripture “seed” refers to first to “Christ” and “Antichrist”, and also to the offspring of God or the Devil (Rev. 12:17; 1 John 3:10 cp. 1 John 2:18)
KJV Revelation 12:1 And there appeared a great wonder in heaven; a woman clothed with the sun, and the moon under her feet, and upon her head a crown of twelve stars:
2 And she being with child cried, travailing in birth, and pained to be delivered.
3 And there appeared another wonder in heaven; and behold a great red dragon, having seven heads and ten horns, and seven crowns upon his heads.
4 And his tail drew the third part of the stars of heaven, and did cast them to the earth: and the dragon stood before the woman which was ready to be delivered, for to devour her child as soon as it was born.
5 And she brought forth a man child, who was to rule all nations with a rod of iron: and her child was caught up unto God, and to his throne.
6 And the woman fled into the wilderness, where she hath a place prepared of God, that they should feed her there a thousand two hundred and threescore days.
7 And there was war in heaven: Michael and his angels fought against the dragon; and the dragon fought and his angels,
8 And prevailed not; neither was their place found any more in heaven.
9 And the great dragon was cast out, that old serpent, called the Devil, and Satan, which deceiveth the whole world: he was cast out into the earth, and his angels were cast out with him.
10 And I heard a loud voice saying in heaven, Now is come salvation, and strength, and the kingdom of our God, and the power of his Christ: for the accuser of our brethren is cast down, which accused them before our God day and night.
11 And they overcame him by the blood of the Lamb, and by the word of their testimony; and they loved not their lives unto the death.
12 Therefore rejoice, ye heavens, and ye that dwell in them. Woe to the inhabiters of the earth and of the sea! for the devil is come down unto you, having great wrath, because he knoweth that he hath but a short time.
13 And when the dragon saw that he was cast unto the earth, he persecuted the woman which brought forth the man child.
14 And to the woman were given two wings of a great eagle, that she might fly into the wilderness, into her place, where she is nourished for a time, and times, and half a time, from the face of the serpent.
15 And the serpent cast out of his mouth water as a flood after the woman, that he might cause her to be carried away of the flood.
16 And the earth helped the woman, and the earth opened her mouth, and swallowed up the flood which the dragon cast out of his mouth.
17 And the dragon was wroth with the woman, and went to make war with the remnant of her seed, which keep the commandments of God, and have the testimony of Jesus Christ. (Rev. 12:1-13:1 KJV)
In this the children of God are manifest, and the children of the devil: whosoever doeth not righteousness is not of God, neither he that loveth not his brother. (1 Jn. 3:10 KJV)
Little children, it is the last time: and as ye have heard that antichrist shall come, even now are there many antichrists; whereby we know that it is the last time. (1 Jn. 2:18 KJV)